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曲霉菌性支气管炎与过敏性支气管肺曲霉病在囊虫纤维化中的免疫分析

Deep immuno-profiling of Aspergillus bronchitis and allergic bronchopulmonary aspergillosis in cysticfibrosis

帝国理工学院

专业介绍
Applications are invited for a Cystic Fibrosis Trust funded 3-year PhD studentship. This studentship is integral to a major Strategic Research Centre in Fungal Immunotherapy (TrIFIC) made to Imperial College London collaborating with the University of Manchester, University of Exeter, University of Massachusetts and Radboud University Nijmegen. The overall aim of the SRC is to systematically define the underlying mechanisms of inflammation in pulmonary aspergillosis in the context of cystic fibrosis. This will enable development of immuno-diagnostic tests to identify which patients will benefit from targeted immunotherapies that can be repurposed in CF-related fungal disease. We are seeking a highly motivated student to join the opportunistic pathogens group led by Dr Darius Armstrong-James within the MRC Centre for Molecular Bacteriology and Infection within the Faculty of Medicine of Imperial College London at the South Kensington Campus. The project is in collaboration with Professor Stuart Elborn (Queen’s Belfast), Professor Rosemary Boyton (Imperial College London), and Professor Frank van der Veerdonk (University of Nijnmegen, the Netherlands) The aim of the project is to undertake deep immunoprofiling of the host response to the major mould pathogen Aspergillus fumigatus in patients with allergic bronchopulmonary aspergillosis and Aspergillus bronchitis. This will allow us to identify those individuals who will have poor outcomes from infection and develop novel targeted immuno-therapeutic approaches for fungal disease. The outstanding international supervisory panel will allow the student the opportunity to be exposed to a range of cutting-edge immunoprofiling techniques for human disease pathogenesis and translational immunotherapy.
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  • 开学时间:
    秋季
  • 申请截止时间:
    7月31日
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申请要点
背景偏好:Applicants must have a first or upper second-class BSc degree from a UK University, or the overseas equivalent, in a relevant area of immunology, biochemistry, chemistry or microbiology. A Master’s degree in one of the above fields and/or experience in immunology would be advantageous. Applicants are also required to meet Imperial College’s English language requirements: http://www.imperial.ac.uk/study/pg/apply/requirements/english/ 招生人:Dr Darius Armstrong-James 招生邮箱:d.armstrong@imperial.ac.uk 招生网页:http://www.imperial.ac.uk/people/d.armstrong
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